Recurrent Pregnancy Loss · ASRM 2026 Navigator
1Overview
2Definition
3Your case
4Testing
5Treatment

Recurrent Pregnancy Loss: What ASRM Recommends in 2026

An interactive guide to the American Society for Reproductive Medicine's updated Committee Opinion — what to test, what to treat, and what to leave alone.

What this tool does

Losing a pregnancy is hard, and losing more than one is harder still. When it happens twice or more, many people are offered a long list of tests and treatments — some helpful, many not.

This guide walks you through the 2026 advice from the American Society for Reproductive Medicine (ASRM). You answer a few questions about your situation, and it shows which tests are worth doing for you, which treatments actually help, and — just as important — which ones the evidence says to skip so you don't waste time, money, or hope on things that don't work.

The most reassuring fact first: for most couples with unexplained recurrent loss, the next pregnancy succeeds without any special treatment at all.

A few numbers worth knowing

50–60%
of first-trimester miscarriages are caused by a chromosomal abnormality in the embryo
ASRM 2026
50–80%
of couples with unexplained RPL succeed in the next pregnancy with no specific treatment
Refs 11, 174
50% → 75%
miscarriage aneuploidy rate, rising from age <35 to age >40
Ref 22
Chromosome problems in the embryo are overwhelmingly random and tied to age — they are not anyone's fault, and finding one usually means the loss was sporadic rather than a sign of something wrong with the parents.

Where the evidence comes from

This tool is built on the ASRM 2026 Recurrent Pregnancy Loss Committee Opinion and 18 supporting studies it cites — every recommendation below traces back to a specific publication.

📚 View the full evidence base →

First: does this meet the ASRM definition?

Recurrent pregnancy loss is a specific diagnosis — not the same as a single miscarriage or infertility.

How many pregnancy losses (under 22 weeks) have there been?Count biochemical/chemical pregnancies confirmed by a positive test. Don't count confirmed molar or ectopic pregnancies.
1 loss
2 losses
3 or more losses

Tell us about the situation

The single most useful piece of information is the chromosome result of the most recent miscarriage. It steers everything that follows.

Was the most recent miscarriage tested for chromosome problems?ASRM recommends array-based (microarray / NGS) testing of the miscarriage tissue for everyone with a 2nd loss or recurrent loss. The result shapes the whole workup.
Tested — abnormal number of chromosomes (aneuploid)
Tested — unbalanced translocation
Tested — normal chromosomes (euploid)
Not tested / result unavailable
Are any of these present? Select all that apply — these flag specific tests. Leave blank if none.
Personal history of a blood clot (thrombosis)
A prior fetal death at or after 10 weeks
Severe preterm pre-eclampsia or placental insufficiency
PCOS (polycystic ovary syndrome)
Overweight / obesity (high BMI)
Age over 40
Family history of diabetes
Past gestational diabetes
Thyroid symptoms or known thyroid risk factors
Irregular/absent periods or breast milk discharge (galactorrhea)
Also having trouble conceiving (concurrent infertility)

Your individualized testing panel

Based on the ASRM 2026 algorithm. Green = recommended for you · amber = consider in your situation · red = ASRM advises against.

The treatment landscape

What ASRM says actually helps, what's uncertain, and what to avoid. Treatments highlighted in orange are the ones most relevant to your case.