Amniotic Fluid EmbolismSMFM 2026 · Interactive checklist
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Live AFE response — running checklist

Everything needed during the event is on this one page: the clocks, the checklist, the weight-based doses and the timed record. Nothing here requires navigating away, because navigating away during a resuscitation would reset the clocks.

Since activationDisplay frozen
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Since CPR started
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Deliver by 4:00 from CPR
Resuscitative hysterotomy
Labs by 5:00 from CPR
Comprehensive panel
OR transfer window 2:00
Tap to run · abandon if it expires
Tranexamic acid over 10:00
Tap to run 1 g IV infusion
Cardiac arrest accompanies many cases of AFE but not all (ref 2). Switching to pulse present retires the arrest-only items and keeps everything else.

Standing instructions — true from the first second

Do not give

Atropine, ondansetron and ketorolac as a routine regimen Evidence for the combination is limited to case reports. Potential harms include worsening kidney function, bleeding coagulopathy, cardiac arrhythmia and myocardial injury. An expert panel recommends against routine use, and the American Heart Association recommends against atropine in the absence of bradycardia. (SMFM 2026 text; refs 10, 19)
Tocolytics — terbutaline, nitroglycerin, magnesium — for the hypertonus of an AFE Uterine hypertonus and fetal bradycardia at the onset of an AFE are signs of the event in progress, not its cause: SMFM states that abnormalities of uterine tone may be the consequence of uterine hypoperfusion from profound shock with massive catecholamine release rather than the cause (ref 2). Tocolysis in a patient with acute pulmonary hypertension, right ventricular failure and hypotension treats the epiphenomenon and worsens the disease. This item is a LiveEvidence annotation, not SMFM text. The 2026 checklist carries no tocolysis warning. The reasoning and the controlled data are set out on the hyperstimulation page.

Weight-based doses

Repeated here so that no one has to leave this page mid-event. The standalone reference version, with the fixed-dose table, is at /doses.

Enter a weight between 30 and 250 kg (66–551 lb).

Timed record & debrief

Post-event debrief — entire team

Recommended soon after transfer to the ICU or, if the patient dies, as soon as feasible. (Figure 1; text)

Registry. Submit all suspected AFE cases, including those with poor outcomes, to the AFE Foundation international registry — afesupport.org/clinician/submit-patient-case. Patient and family support resources: National Partnership for Maternal Safety consensus bundle (ref 13). Staff second-victim needs: ref 14.

Timed record

No events recorded yet.

Times are elapsed from activation, with the CPR clock in brackets. Wall-clock times let the record be reconciled with the chart. Copy or print before closing the tab — nothing is stored, and closing discards the record.